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Brand: Terraternal

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Carnosine is a life extension superstar for its versatility and potency. In particular, it combats glycation, free radical damage, replicative senescence, telomere shortening and is a chelator of heavy metals. In addition, it has been found to extend the lifespan in mice by 20%.

CARNOSINE

Glycation and Oxidation

Carnosine has been known for some time now to be very effective in guarding against glycation, the insidious and devastating process over time by which tissues, particularly those of the nervous system, are irreversibly damaged by their permanent combination with sugar molecules. There are a large number of studies at this point, both in vivo and in vitro, demonstrating its efficacy as an anti-glycating agent on a wide array of different tissues and cell types including those of the nervous system and lens of the eye.1,2 In addition to protecting proteins from glycation, it also protects them from oxidation.3 In particular, it has the ability to neutralize the most destructive of protein-oxidizing free radicals – the hydroxyl radical. It was declared by one study to be the only anti-oxidant capable of protecting DNA from oxidation,4 and is key in the body’s ability to repair and remove proteins already damaged by glycation or oxidation.

Protects the eye...

...and the nervous system from glycation.

Protects DNA from oxidation.

Replicative Senescence and Telomere Shortening

As the body’s cells divide telomeres shorten, and due to the telomere position effect, the new cells are ‘older’ or more dysfunctional on a number of fronts. Eventually they become ‘senescent’ where they radically change shape, stop dividing and wait for death. These cells represent the final stage of degradation due to telomere-mediated cellular aging. We believe telomere shortening is the one true underlying cause of aging in all species, so anything that may slow down this process is invaluable to us. And Carnosine has recently been shown to both slow telomere shortening5 and independently, to delay and even revert6 replicative senescence.7

Can delay and even revert replicative senesence..

Slows telomere shortening.

In Vivo Life Extension

One study tested the effect of carnosine on life span and indicators of aging in senescence-accelerated mice. Carnosine extended the life span of the treated mice by 20% on average although the maximum lifespan was not altered.8

Warnings

Non recommandé pour les femmes en ceinte ou femmes qui allaitent. Tenir hors de portée des enfants. Conserver dans un endroit frais et sec.

Money Back Guarantee

If for any reason you are unsatisfied with a Terraternal product, simply return the unused portion to us within 30 days for a full refund. No questions asked.

Product Code: TRLC002
Package Quantity: 60 capsules
Shipping Weight: 2.0000 lbs
Serving Size: 1 capsule
 

L-Carnosine Supplement Facts


 Supplement Amount Per Serving % Daily Value
 L-Carnosine 500 mg †
 † Daily Value not established  
   

References:

  • 1.
    Reddy VP, Garrett MR, Perry G, Smith MA (May 2005). "Carnosine: a versatile antioxidant and antiglycating agent". Science of Aging Knowledge Environment 2005 (18):pe12. doi:10.1126/sageke.2005.18.pe12. PMID 15872311.

    Rashid I, van Reyk DM, Davies MJ (March 2007). "Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro". FEBS Letters 581(5):1067–70. doi:10.1016/j.febslet.2007.01.082. PMID 17316626.

    Carnosine protected against the adverse effects of high glucose levels on renal cells. Janssen, B. 2005.

    Carnosine inhibited glycation of actyl-Lys-His-amide by dihydroxyacetone and it protected a-crystallin, superoxide dismutase and catalase against glycation. Hipkiss, A. 1995.

    Carnosine showed as an antiglycation agent and its mechanism of action involves prevention of protein modification. Seidler, N. 1999.

    Carnosine protected a-crystallin (a major structural protein in the lens of the eyes) against glycation by a sugar and a sugar phosphate. Yan, H. 2006.

    Carnosine could suppress the formation of advanced glycation end-products initiated by peritoneal dialysis fluid. Alhamdani, M. 2007.

    Carnosine decreased the enthalpy of denaturation, suggesting that carnosine may promote hydration during heat denaturation of glycated protein. Yeargans, G. 2002.
  • 2.
    Hobart et al. Anti-crosslinking properties of carnosine: significance of histidine. Life Sci. 75:1379-89 (2004).
  • 3.
    "C9625 L-Carnosine ~99%, crystalline". Sigma-Aldrich.

    Aruoma OI, Laughton MJ, Halliwell B (December 1989). "Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo?". The Biochemical Journal 264(3):863–9. PMID 2559719.

    Choi SY, Kwon HY, Kwon OB, Kang JH (November 1999). "Hydrogen peroxide-mediated Cu,Zn-superoxide dismutase fragmentation: protection by carnosine, homocarnosine and anserine". Biochimica et Biophysica Acta 1472(3):651–7. doi:10.1016/S0304-4165(99)00189-0. PMID 10564779.

    Klebanov GI, Teselkin YuO, Babenkova IV, et al. (1998). "Effect of carnosine and its components on free-radical reactions". Membrane & Cell Biology 12(1):89–99. PMID 9829262.

    Babizhayev MA, Seguin MC, Gueyne J, Evstigneeva RP, Ageyeva EA, Zheltukhina GA (December 1994). "L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities". The Biochemical Journal 304(2):509–16. PMID 7998987.

    Chan KM, Decker EA (1994). "Endogenous skeletal muscle antioxidants". Critical Reviews in Food Science and Nutrition 34(4):403–26.doi: 10.1080/10408399409527669. PMID 7945896.

    Ozel Turkcu U, Bilgihan A, Biberoglu G, Mertoglu Caglar O (January 2010). "Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stress". Molecular and Cellular Biochemistry 339(1-2):55–61. doi:10.1007/s11010-009-0369-x. PMID 20047045.
  • 4.
    Preston JE, Hipkiss AR, Himsworth DT, et al. Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine. Neurosci Lett. 1998; 242(2):105-8.

    T. A. Leinsoo, H. Abe and A. A. Boldyrev, Carnosine and related compounds protect the double-chain DNA from oxidative damages, JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY Volume 42, Number 5, 570-574. (http://www.springerlink.com/content/a735p80736533511/)
  • 5.
    Shao L; Li QH, Tan Z (2004). "L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts". Biochem Biophys Res Commun. 324(2):931-93
  • 6.
    The reversion of senescent cells to cells of a normal phenotype seems to only last, however, as long as the cells continue to be exposed to Carnosine:

    We have shown that late-passage HFF-1 cells retain a juvenile appearance in medium containing 50 mM carnosine, and revert to a senescent phenotype when carnosine is removed (From G., above ..ibid)
  • 7.
    McFarlan GA.; Holliday R. (1994). "Retardation of the senescence of cultured human fibroblasts by carnosine". Exp. Cell Res. 212(2):167–175. doi:10.1006/excr.1994.1132.PMID 8187813.

    McFarland GA et al. 1999. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res. 1994 Jun; 212(2):167-75.

    McFarland GA, Holliday R. We have examined the effects of the naturally occurring dipeptide carnosine (beta-alanyl-L-histidine) on the growth, morphology, and lifespan of cultured human diploid fibroblasts. With human foreskin cells, HFF-1, and fetal lung cells, MRC-5, we have shown that carnosine at high concentrations (20-50 mM) in standard medium retards senescence and rejuvenates senescent cultures. These late-passage cultures preserve a nonsenescent morphology in the presence of carnosine, in comparison to the senescent morphology first described by Hayflick and Moorhead. Transfer of these late-passage cells in medium containing carnosine to unsupplemented normal medium results in the appearance of the senescent phenotype. The serial subculture of cells in the presence of carnosine does not prevent the Hayflick limit to growth, although the lifespan in population doublings as well as chronological age is often increased. This effect is obscured by the normal variability of human fibroblast lifespans, which we have confirmed. Transfer of cells approaching senescence in normal medium to medium supplemented with carnosine rejuvenates the cells but the extension in lifespan is variable. Neither D-carnosine, (beta-alanyl-D-histidine), homocarnosine, anserine, nor beta-alanine had the same effects as carnosine on human fibroblasts. Carnosine is an antioxidant, but it is more likely that it preserves cellular integrity by its effects onprotein metabolism.
  • 8.
    Yuneva MO, Bulygina ER, Gallant SC, et al. Effect of carnosine on age-induced changes in senescence-accelerated mice. J Anti-Aging Med. 1999; 2(4):337-42.