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Back Ascorbic Acid 2-Phosphate (Asc2P) - 150 mg, 60 capsules

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Brand: Terraternal

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Asc2P Slowed Telomere Shortening by Over 50%

Ascorbic Acid 2-Phosphate (Asc2P) is a rare form of Vitamin C that is very effective in slowing telomere shortening in vitro. In this study1, it was shown that repetitive addition of Asc2P to human endothelial cells in vitro slowed telomere shortening by a dramatic 52-62%2

Shortening rate reduction

52-62%
 

Vitamin C vs Asc2P

The authors found in two back to back studies that standard Vitamin C (ascorbic acid) had no effect on telomere length.3. They found that Asc2P results in 3.9 times higher intracellular levels of Vitamin C4 than exposure to standard Vitamin C and described it as acting as a sort of intracellular time-release capsule of Vitamin C5. Asc2P was able to reduce the level of a key type of free radical ('reactive oxygen intermediate') within the cell to 53% of control level6.

Method of Action

Because no telomerase upregulation was detected after the addition of Asc2P, the authors speculated that the slowdown in shortening came from Asc2P's ability to combat free radicals and prevent telomere shortening that is the result of free radical damage and not associated with cell division.7

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Product Code: TRC2P001
Package Quantity: 60 capsules
Shipping Weight: 2.1000 lbs
Serving Size: 1 capsule
 

Ascorbic Acid 2-Phosphate (Asc2P) Supplement Facts


 Supplement Amount Per Serving % Daily Value
 Vitamin C (as ascorbic acid 2-phosphate) 150mg 250%
   

References
  • 1.
    Yokoo, Furumoto, et al. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 1998;63(11):935-48.
  • 2.
    Ibid. Page 935, paragraph 1
  • 3.
    Ibid. Page 936, paragraph 3.

    and

    Yokoo, Furumoto. Slow-Down of Age-Dependent Telomere Shortening Is Executed in Human Skin Keratinocytes by Hormesis-Like-Effects of Trace Hydrogen Peroxide or by Anti-Oxidative Effects of Pro-Vitamin C in Common Concurrently With Reduction of Intracellular Oxidative Stress. Journal of Cellular Biochemistry 93:588–597 (2004)
    Page 595, paragraph 1.
  • 4.
    Ibid. Page 935, paragraph 1
  • 5.
    "Asc2P can maintain the intracellular Asc concentrations at higher levels through gradual release of Asc"

    Yokoo, Furumoto. Slow-Down of Age-Dependent Telomere Shortening Is Executed in Human Skin Keratinocytes by Hormesis-Like-Effects of Trace Hydrogen Peroxide or by Anti-Oxidative Effects of Pro-Vitamin C in Common Concurrently With Reduction of Intracellular Oxidative Stress. Journal of Cellular Biochemistry 93:588–597 (2004) Page 595, paragraph 1.
  • 6.
    Yokoo, Furumoto, et al. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 1998;63(11):935-48.
    Page 935, paragraph 1.
  • 7.
    "Telomeres may suffer from less DNA lesions due to the continuous and thorough repression of intracellular ROS, which was realized either by pro-vitamin C such as Asc2P or Asc2G that exerted an antioxidant ability more persistent than Asc itself"
    Yokoo, Furumoto. Slow-Down of Age-Dependent Telomere Shortening Is Executed in Human Skin Keratinocytes by Hormesis-Like-Effects of Trace Hydrogen Peroxide or by Anti-Oxidative Effects of Pro-Vitamin C in Common Concurrently With Reduction of Intracellular Oxidative Stress. Journal of Cellular Biochemistry 93:588–597 (2004)

    Page 588, paragraph 1.

    With a shortening rate decrease as high of 50-60%, however, perhaps there is something else going on with Asc2P's influence on the complex molecular biology associated with telomere length regulation mechanisms which are only now beginning to be understood.