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Back Terminalia Chebula - 250 mg, 60 capsules

Brand: Terraternal

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Overview

The fruit of Terminalia Chebula, commonly known as Black Myrobalan, is a popular plant that has been used in ayurvedic medicine to treat a number of ailments.

Terminalia Chebula Slowed Telomere Shortening by 45% In Vitro

Recently, its effect on telomere shortening was studied and Terminalia Chebula was found to slow it down by 45% in vitro1. In the study, human skin cells (epidermal keratinocytes)2 were cultured with and without continual administration of Terminalia Chebula. The telomeres of the treated cells were found to shorten at a rate of 192 base pairs per doubling (bp/PDL) while the control cells lost telomere length almost twice as fast - 342 bp/PDL3.

Shortening rate reduction

45%
 

As a result, the treated cells were able to divide 40% more before reaching the Hayflick Limit and becoming senescent.4

Method of Action

It has recently been established that oxidative stress accelerates telomere loss5. The authors tested Terminalia Chebula's effect both on oxidative stress and telomere shortening and concluded that "T. chebula extract could slow down the telomere shortening rate by inhibition of oxidative stress."6

Warnings

Not recommended for pregnant or lactating women. Keep out of reach of children. Store in a cool, dry place and away from direct light.

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If for any reason you are unsatisfied with a Terraternal product, simply return the unused portion to us within 30 days for a full refund. No questions asked.

Product Code: TRTC001
Package Quantity: 60 capsules
Shipping Weight: 1.6000 lbs
Serving Size: 1 capsule
 

Terminalia Chebula Supplement Facts


 Supplement Amount Per Serving % Daily Value
 Myrobalan Fruit 10:1 Extract (Terminalia Chebula) 250 mg †
 † Daily Value not established  
   

References:

  • 1.
    MinKyan NA, KiHwan et al. (2004 ). "Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit". Phytotherapy Research 18, 737–741
    "It was observed that in the case of the cells administered to the T. chebula extract, the telomere length had shortened by an average of 192 bp/PDL, which was slower than the 342 bp/PDL observed in the control group."

    Page 739, paragraph 4.

    192/342 = 55%. 100%-55% = 45% reduction rate in telomere shortening.
  • 2. Ibid, page 737, paragraph 3.
  • 3. Ibid, page 739, paragraph 4.
  • 4. Ibid, page 739, paragraph 3.
  • 5.
    Yokoo, Furumoto, et al. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 1998;63(11):935-48.

    Lorenz M, Saretzki G, Sitte N, et al. 2001. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic Biol Med 31: 824–831.

    Saretzki G, von Zglinicki T. 2002. Replicative aging, telomeres, and oxidative stress. Ann N Y Acad Sci 959: 24–29.
  • 6. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit, Ibid. Page 740, paragraph 1.