Resveratrol Bioavailability in Humans
It was recently discovered that the bioavailability of resveratrol in humans, which is typically measured by the amount of resveratrol in blood plasma, is essentially zero. Despite industry efforts to increase absorption, this is not the problem, because resveratrol absorption is already unusually excellent at 70%. The problem is metabolism. The resveratrol molecule, also known as free or aglycone resveratrol is metabolized by the liver and small intestine and
converted almost entirely to resveratrol glucuronide and sulfate before reaching the bloodstream. Our Sublingual/Buccal Resveratrol tablets allow free resveratrol to directly enter the bloodstream. Read More.
Why Use Sublingual/Buccal Resveratrol?
Because it is the only way to get unaltered (aglycone) resveratrol into your body, and unaltered resveratrol is the basis of almost all in vitro resveratrol research.
Because techniques that increase absorption are not effective against first-pass metabolism, which converts resveratrol to other substances before it enters the bloodstream.
To guard against the possibility that standard oral supplementation is ineffective due to the near-zero bioavailability of free resveratrol in humans.
Questions on the Bioavailability of Resveratrol
We know that rats and mice also convert resveratrol into metabolites as do humans. This news is encouraging for the standard supplementation of resveratrol, as the result of studies in rats and mice in in vivo studies of resveratrol have been very positive. Particularly in the Sinclair study involving mice, there was substantial evidence of SIRT1 activation in vivo. So it appears that somehow the resveratrol continues to work its magic, despite the metabolism/conversion. However, in rats the metabolites are reversed and the sulfate form is dominant. Finally, almost every resveratrol in vitro study so far has employed direct exposure to free resveratrol, and not the metabolites. This gives rise to doubts about the efficacy of standard resveratrol supplementation in humans. So for those who simply want to cover all their bases, we offer Sublingual/Buccal Resveratrol, a product that delivers free resveratrol directly into the bloodstream via sublingual glands below the tongue and / or membranes inside the cheek.
Take one or more tablets and let dissolve for at least a minute or until it dissolves completely.
For more information on the bioavailability of resveratrol in humans click here .
For more information about the general benefits of resveratrol, see our product here .
Money Back Guarantee
If for any reason you are unsatisfied with a Terraternal product, simply return the unused portion to us within 30 days for a full refund. No questions asked.