 Glycation
Benfotiamine
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Diabetes
Benfotiamine aided the post-ischaemic healing of diabetic animals via PKB/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. In addition, benfotiamine combated the diabetes-induced deficit in endothelial progenitor cells.
Gadau, S. 2006
Hyperglycemia (high blood sugar) impaired endothelial cell differentiation and that process was restored by benfotiamine administration.
Marchetti V 2006
Glycation
Benfotiamine prevented Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress following a meal rich in advanced glycation end products in individuals With Type 2 Diabetes.
Stirban, A. 2006
High-dose therapy with thiamine and Benfotiamine suppressed the accumulation of AGEs, showing it may be a novel approach to preventing the development of diabetic complications.
Karachalias, N. 2003
Thiamine and benfotiamine prevented increased apoptosis in endothelial cells and pericytes cultured in high glucose.
Beltramo E 2004
Benfotiamine induced a major inhibition of neural imidazole-type AGE formation and completely prevented diabetes induced glycoxidation products in a group of animals.
Stracke, H. 2001
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