 Silent Inflammation
Resveratrol
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Life Extension
Resveratrol improved health and survival of mice on a high-calorie diet.
Sinclair 2006
Resveratrol prolonged lifespan and retards the onset of age-related markers in a short-lived vertebrate.
Valenzano, D. 2006
Resveratrol extended life of yeast by 70% and produces some gene expression changes consistent with those caused by caloric restriction.
Howitz, K. 2003
Resveratrol delayed or inhibits replicative aging in cells.
Stefani, M. 2007
Resveratrol activated continuous telomerase activity with 24 h in Li-Fraumeni syndrome-dervied breast epithelial cells.
Pearce, Shay 2007
Cancer
Resveratrol inhibited autocrine growth modulators in human breast cancer cells.
Serrero, G. 2001
Resveratrol was shown to inhibit tumor initiation, promotion and progression phases, as well as supress the final steps of carcinogenesis, i.e. angiogenesis and metastasis.
Delmas 2006
Resveratrol supressed DBMA-included breast cancer in rats.
Whitsett, T. 2006
Resveratrol induced a decrease in proliferation rates and an increase in apoptosis (cell suicide) in cancer cell lines in a dose-and time-dependent manner.
Benitez 2007
Resveratrol promoted cell death in colon cancer cells.
Mohan 2006
Resveratrol inhibited tumor growth of human neuroblastoma.
Van Ginkel PR 2007
Resveratrol supplementation delayed the development of spontaneous mammary tumors, reduced the mean number and size of mammary tumors and diminished the number of lung metastases in HER-2/neu transgenic mice.
Provinciali, M. 2005
Resveratrol regulated apoptosis and cell survival in mouse skin tumors as a mechanism of chemoprevention.
Roy, P. 2008
Telomerase Activation
Epithelial progenitor cells with mutant p53, but not wild-type p53, were immortalized, and telomerase was upregulated, by exposure to resveratrol.
Shay 2007
Resveratrol dose dependently prevented the onset of endothelial progenitor cells (EPCs) senescence and increased their proliferation and migration. Resveratrol significantly increased telomerase activity in these cells.
Xia L 2008
Caloric Restriction Mimetic
Resveratrol delayed age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan
Pearson 2008
Telomerase Inhibition
Relatively high concentrations of Resveratrol were found to be able to substantially down-regulate telomerase activity in WiDr human colon cancer cell lines.
Fuggetta MP 2006
TRAP assay and Western blot analysis respectively showed that resveratrol treatment down-regulates the telomerase activity of target [human metastatic breast cancer cells] cells.
Pearce VP 2008
Life Extension
entered by: jwilde
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